Programmed ribosomal frameshifting: Much ado about knotting!

Programmed ribosomal frameshifting: much ado about knotting!

R of the genetic code can be temporarily suspended to make room for a variety of specific tricks that direct synthesis of additional proteins from mRNAs that would not be predicted by their sequences. This ‘‘recoding’’ includes specification of the 21st encoded amino acid, selenocysteine (1, 2). In another form, recoding itself provides a sensing mechanism to regulate expression (3). In other c...

Much ado about nothing?

I t all started with the submission of an unsolicited review on idiopathic pulmonary haemosiderosis by IOACHIMESCU et al. [1]. During the review process of this excellent manuscript, the idea evolved to launch a whole series on rare (orphan) interstitial lung disorders in the European Respiratory Journal. Why bother? Well, admittedly, these diseases are rare, but for the affected patient that d...

Much ado about nothing?

Much Ado about Nogo

Three proteins in mature myelin (Nogo, MAG, and OMgp) have been purported to be critical in causing both regenerative failure and minimal sprouting after CNS injury. However, the role of this repulsive trio in vivo has been controversial. Lee et al., in this issue of Neuron, provide evidence that genetically deleting all three major myelin inhibitors either singly or all together does not resul...

Much ado about nothing.